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Fractional-Continuous Wavelet Transforms and Ultra-Performance Liquid Chromatography for the Multicomponent Analysis of A Ternary Mixture Containing Thiamine, Pyridoxine, and Lidocaine in Ampules

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dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2020-04-07T19:27:38Z
dc.date.available 2020-04-07T19:27:38Z
dc.date.issued 2012-05
dc.identifier.citation Dinc, Erdal; Baleanu, Dumitru, "Fractional-Continuous Wavelet Transforms and Ultra-Performance Liquid Chromatography for the Multicomponent Analysis of a Ternary Mixture Containing Thiamine, Pyridoxine, and Lidocaine in Ampules", Journal of Aoac International, Vol. 95, No. 3, pp. 903-912, (2012) tr_TR
dc.identifier.issn 1060-3271
dc.identifier.uri http://hdl.handle.net/20.500.12416/2963
dc.description.abstract New chemometric approaches based on the application of partial least squares (PLS) and principal component regression (PCR) algorithms with fractional wavelet transform (FWT) and continuous wavelet transform (CWT) are proposed for the spectrophotometric multicomponent determination of thiamine hydrochloride (B-1), pyridoxine hydrochloride (B-6), and lidocaine hydrochloride (LID) in ampules without any separation step. In this study PLS and PCR techniques were applied to the raw spectral data, FWT-coefficients, and FWT-CWT-coefficients. These calibration models were labeled as Raw-PLS and Raw-PCR, FWT-PLS and FWT-PCR, and FWT-CWT-PLS and FWT-CWT-PCR, respectively. A new ultra-performance liquid chromatographic (UPLC) method was developed for the comparison of the results obtained by applying the chemometric calibration methods. Chromatographic separation and determination of B-1, B-6, and LID in ampules were performed on an Acquity UPLC (R) BEH C18 column (50 x 2.1 mm id, 1.7 mu m particle size) using gradient elution with a mobile phase consisting of methanol and 0.01 M HCl at a constant flow rate of 0.6 mL/min. These combined chemometric calibrations and UPLC were validated by analyzing various ternary mixtures, B-1, B-6, and LID. The proposed chemometric approaches (signal processing-multivariate calibrations) and UPLC method were applied to the quantitative multicomponent analysis of marketed ampules containing the vitamins B1 and B-6 with LID. tr_TR
dc.language.iso eng tr_TR
dc.publisher AOAC International tr_TR
dc.relation.isversionof 10.5740/jaoacint.11-199 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Continuous Daubechies tr_TR
dc.subject Hcl tr_TR
dc.subject Hydrochlorothiazide tr_TR
dc.subject Multidetermination tr_TR
dc.subject Suppositories tr_TR
dc.subject Acetate tr_TR
dc.subject Spectra tr_TR
dc.title Fractional-Continuous Wavelet Transforms and Ultra-Performance Liquid Chromatography for the Multicomponent Analysis of A Ternary Mixture Containing Thiamine, Pyridoxine, and Lidocaine in Ampules tr_TR
dc.type article tr_TR
dc.relation.journal AOAC International tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 95 tr_TR
dc.identifier.issue 3 tr_TR
dc.identifier.startpage 903 tr_TR
dc.identifier.endpage 912 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bölümü tr_TR


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