Abstract:
Modern science having embarked on the thorough and accurate interpretation of natural and physical phenomena has proven to provide successful models for the analysis of complex systems and harnessing of control over the various processes therein. Computational complexity, in this regard, comes to the foreground by providing applicable sets of ideas or integrative paradigms to recognize and understand the complex systems' intricate properties. Thus, while making the appropriate, adaptable and evolutive decisions in complex dynamic systems, it is essential to acknowledge different degrees of acceptance of the problems and construct the model it to account for its inherent constraints or limits. In this respect, while hypothesis-driven research has its inherent limitations regarding the investigation of multifactorial and heterogeneous diseases, a data-driven approach enables the examination of the way variables impact one another, which paves the way for the interpretation of dynamic and heterogeneous mechanisms of diseases. Fractional Calculus (FC), in this scope characterized by complexity, provides the applicable means and methods to solve integral, differential and integro-differential equations so FC enables the generalization of integration and differentiation possible in a flexible and consistent manner owing to its capability of reflecting the systems' actual state properties, which exhibit unpredictable variations. The fractional integration and differentiation of fractional-order is capable of providing better characterization of nonstationary and locally self-similar attributes in contrast to constant-order fractional calculus. It becomes possible to model many complex systems by fractional-order derivatives based on fractional calculus so that related syntheses can be realized in a robust and effective way. To this end, our study aims at providing an intermediary facilitating function both for the physicians and individuals by establishing accurate and robust model based on the integration of fractional-order calculus and Artificial Neural Network (ANN) for the diagnostic and differentiability predictive purposes with the diseases which display highly complex properties. The integrative approach we have proposed in this study has a multistage quality the steps of which are stated as follows: first of all, the Caputo fractional-order derivative, one of the fractional-order derivatives, has been used with two-parametric Mittag-Leffler function on the stroke dataset and cancer cell dataset, manifesting biological and neurological attributes. In this way, new fractional models with varying degrees have been established. Mittag-Leffler function, with its distributions of extensive application domains, can address irregular and heterogeneous environments for the solution of dynamic problems; thus, Mittag-Leffler function has been opted for accordingly. Following this application, the new datasets (mlf_stroke dataset and mlf_cancer cell dataset) have been obtained by employing Caputo fractional-order derivative with the two-parametric Mittag-Leffler function In addition, classical derivative (calculus) was applied to the raw datasets; and cd_stroke dataset and cd_cancer cell dataset were obtained. Secondly, the performance of the new datasets as obtained from the Caputo fractional derivative with the two-parametric Mittag-Leffler function, the datasets obtained from the classical derivative application and the raw datasets have been compared by using feed forward back propagation (FFBP) algorithm, one of the algorithms of ANN (along with accuracy rate, sensitivity, precision, specificity, F1-score, multiclass classification (MCC), ROC curve). Based on the accuracy rate results obtained from the application with FFBP, the Caputo fractional-order derivative model that is most suitable for the diseases has been generated. The experimental results obtained demonstrate the applicability of the complex-systems-grounded paradigm scheme as proposed through this study, which has no existing counterpart. The integrative multi-stage method based on mathematical-informed framework with comparative differentiability prediction analyses can point toward a new direction in the various areas of applied sciences to address formidable challenges of critical decision making and management of chaotic processes in different complex dynamic systems.