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Spectrophotometry simultaneous determination of levamisole and triclabendazole in tablets by principal component regression and partial least squares chemometric methods

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dc.contributor.author Pektas, Gözde
dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2024-04-25T07:32:08Z
dc.date.available 2024-04-25T07:32:08Z
dc.date.issued 2008-02
dc.identifier.citation Pektas, Gözde; Dinç, Erdal; Baleanu, D. (2008). "Spectrophotometry simultaneous determination of levamisole and triclabendazole in tablets by principal component regression and partial least squares chemometric methods", Revista de Chimie, Vol.59, No.2, pp.154-158. tr_TR
dc.identifier.issn 00347752
dc.identifier.uri http://hdl.handle.net/20.500.12416/7929
dc.description.abstract Principal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of levamisole (LVM) and triclabendazole (TCB) in tablets without using a preliminary separation, even in presence of the overlapping spectra of the above compounds. For both PCR and PLS, a concentration set containing 25 different mixtures of LVM and TCB in the linear concentration range was symmetrically prepared and then the absorbance values of the concentration set were measured at the wavelength set with Δλ=0.1 nm in the spectral region of 225-322.3 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. Then, these analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples. tr_TR
dc.language.iso eng tr_TR
dc.relation.isversionof 10.37358/rc.08.2.1724 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Levamisole tr_TR
dc.subject Partial Least Squares tr_TR
dc.subject Principal Component Regression tr_TR
dc.subject Triclabendazole tr_TR
dc.title Spectrophotometry simultaneous determination of levamisole and triclabendazole in tablets by principal component regression and partial least squares chemometric methods tr_TR
dc.type article tr_TR
dc.relation.journal Revista de Chimie tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 59 tr_TR
dc.identifier.issue 2 tr_TR
dc.identifier.startpage 154 tr_TR
dc.identifier.endpage 158 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen-Edebiyat Fakültesi, Matematik Bölümü tr_TR


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