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Spectrophotometric simultaneous determination of atorvastatin-amlodipin and telmisartan-hidrochlorothiazide mixtures by bivariate and multivariate calibrations

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dc.contributor.author Demirbilek, Mehmet Paşa
dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2016-06-13T11:28:26Z
dc.date.available 2016-06-13T11:28:26Z
dc.date.issued 2010-06
dc.identifier.citation Demirbilek, M.P., Dinç, E., Baleanu, D. (2010). Spectrophotometric simultaneous determination of atorvastatin-amlodipin and telmisartan-hidrochlorothiazide mixtures by bivariate and multivariate calibrations. Revista De Chimie, 61(6), 532-540. tr_TR
dc.identifier.issn 0034-7752
dc.identifier.uri http://hdl.handle.net/20.500.12416/1087
dc.description.abstract The bivariate and multivariate spectral calibrations were proposed for the simultaneous quantitative analysis of two different mixtures containing atorvastatin-amlodipine and telmisartan- hydrochlorothiazide combinations in tablets. These methods do not require any separation step of the related compounds in the same mixtures. In the first case, the bivariate spectral calibration (BC) was obtained by using four linear regression functions with two single-component regressions for each compound at the two-wavelength sets 218, 260 nm for ATO-AML mixture and 224, 236 nm for TEL-HCT mixture. In the second case, the multivariate spectral calibration (MC) was performed by the simultaneous use of 26 linear regression equations with 26 single-component regression for each compound at a 26-wavelength set from 218 nm to 268 nm with the intervals of Delta lambda = 2 nm for ATO-AML mixture and at a 26-wavelength set from 220 nm to 320 nm with the intervals of Delta lambda = 4 nm for TEL-HCT mixture. All the methods were validated by analysing the synthetic mixture of two active compounds and by using standard addition technique. The obtained results were successfully compared with each other and both methods were successfully applied to the quantitative evaluation of two different mixtures consisting of ATO-AML and TEL-HCT tr_TR
dc.language.iso eng tr_TR
dc.publisher Chiminform Data S A tr_TR
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Bivariate and Multivariate Calibrations tr_TR
dc.subject Linear Regression Function tr_TR
dc.subject Atorvastatin-Amlodipine and Telmisartan-Hydrochlorothiazide Tablets tr_TR
dc.title Spectrophotometric simultaneous determination of atorvastatin-amlodipin and telmisartan-hidrochlorothiazide mixtures by bivariate and multivariate calibrations tr_TR
dc.type article tr_TR
dc.relation.journal Revista De Chimie tr_TR
dc.contributor.authorID 6981 tr_TR
dc.identifier.volume 61 tr_TR
dc.identifier.issue 6 tr_TR
dc.identifier.startpage 532 tr_TR
dc.identifier.endpage 540 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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