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Modeling, inference and optimization of regulatory networks based on time series data

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dc.contributor.advisor
dc.contributor.author Weber, Gerhard Wilhelm
dc.contributor.author Defterli, Özlem
dc.contributor.author Alparslan Gök, Sırma Zeynep
dc.contributor.author Kropat, Erik
dc.date.accessioned 2016-07-01T08:29:07Z
dc.date.available 2016-07-01T08:29:07Z
dc.date.issued 2011-05-16
dc.identifier.citation Weber, G.W...et al. (2011). Modeling, inference and optimization of regulatory networks based on time series data. European Journal of Operational Research, 211(1), 1-14. http://dx.doi.org/10.1016/j.ejor.2010.06.038 tr_TR
dc.identifier.issn 0377-2217
dc.identifier.uri http://hdl.handle.net/20.500.12416/1174
dc.description.abstract In this survey paper, we present advances achieved during the last years in the development and use of OR, in particular, optimization methods in the new gene-environment and eco-finance networks, based on usually finite data series, with an emphasis on uncertainty in them and in the interactions of the model items. Indeed, our networks represent models in the form of time-continuous and time-discrete dynamics, whose unknown parameters we estimate under constraints on complexity and regularization by various kinds of optimization techniques, ranging from linear, mixed-integer, spline, semi-infinite and robust optimization to conic, e.g., semi-definite programming. We present different kinds of uncertainties and a new time-discretization technique, address aspects of data preprocessing and of stability, related aspects from game theory and financial mathematics, we work out structural frontiers and discuss chances for future research and OR application in our real world tr_TR
dc.language.iso eng tr_TR
dc.publisher Elsevier Science Bv tr_TR
dc.relation.isversionof 10.1016/j.ejor.2010.06.038 tr_TR
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Nonlinear Programming tr_TR
dc.subject Uncertainty Modeling tr_TR
dc.subject Computational Biology tr_TR
dc.subject Environment tr_TR
dc.subject Games tr_TR
dc.subject Data Mining tr_TR
dc.title Modeling, inference and optimization of regulatory networks based on time series data tr_TR
dc.type article tr_TR
dc.relation.journal European Journal of Operational Research tr_TR
dc.contributor.authorID 31401 tr_TR
dc.contributor.authorID 107899 tr_TR
dc.identifier.volume 211 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 1 tr_TR
dc.identifier.endpage 14 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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