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Clinoptilolite/PCL-PEG-PCL composite scaffolds for bone tissue engineering applications

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dc.contributor.author Pazarçeviren, Engin
dc.contributor.author Erdemli, Özge
dc.contributor.author Keskin, Dilek
dc.contributor.author Tezcaner, Ayşen
dc.date.accessioned 2020-03-18T11:32:01Z
dc.date.available 2020-03-18T11:32:01Z
dc.date.issued 2017-03
dc.identifier.citation Pazarceviren, Engin...et al. (2017)."Clinoptilolite/PCL-PEG-PCL composite scaffolds for bone tissue engineering applications", Journal Of Biomaterials Applications, Vol.31, No.8, pp.1148-1168. tr_TR
dc.identifier.issn 0885-3282
dc.identifier.uri http://hdl.handle.net/20.500.12416/2665
dc.description.abstract The aim of this study was to prepare and characterize highly porous clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite scaffolds. Scaffolds with different clinoptilolite contents (10% and 20%) were fabricated with reproducible solvent-free powder compression/particulate leaching technique. The scaffolds had interconnective porosity in the range of 55-76%. Clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)poly(epsilon-caprolactone) scaffolds showed negligible degradation within eight weeks and displayed less water uptake and higher bioactivity than poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) scaffolds. The presence of clinoptilolite improved the mechanical properties. Highest compressive strength (5.6 MPa) and modulus (114.84 MPa) were reached with scaffold group containing 20% clinoptilolite. In vitro protein adsorption capacity of the scaffolds was also higher for clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) scaffolds. These scaffolds had 0.95 mg protein/g scaffold adsorption capacity and also higher osteoinductivity in terms of enhanced ALP, OSP activities and intracellular calcium deposition. Stoichiometric apatite deposition (Ca/P = 1.686) was observed during cellular proliferation analysis with human fetal osteoblasts cells. Thus, it can be suggested that clinoptilolite/poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) composite scaffolds could be promising carriers for enhancement of bone regeneration in bone tissue engineering applications. tr_TR
dc.language.iso eng tr_TR
dc.publisher Sage Publications LTD tr_TR
dc.relation.isversionof 10.1177/0885328216680152 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Clinoptilolite tr_TR
dc.subject PCL-PEG-PCL tr_TR
dc.subject Particulate Leaching tr_TR
dc.subject Solvent-Free tr_TR
dc.subject Powder Compression tr_TR
dc.subject Bone Tissue Engineering tr_TR
dc.title Clinoptilolite/PCL-PEG-PCL composite scaffolds for bone tissue engineering applications tr_TR
dc.type article tr_TR
dc.relation.journal Journal Of Biomaterials Applications tr_TR
dc.contributor.authorID 163717 tr_TR
dc.identifier.volume 31 tr_TR
dc.identifier.issue 8 tr_TR
dc.identifier.startpage 1148 tr_TR
dc.identifier.endpage 1168 tr_TR
dc.contributor.department Çankaya Üniversitesi, Mühendislik Fakültesi, Malzeme Bilimi ve Mühendisliği Bölümü tr_TR


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