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Simultaneous determination of quinapril and hydrochlorothiazide in tablets by ratio spectra derivative spectrophotometric and chemometric methods

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dc.contributor.author Dinç, Erdal
dc.contributor.author Altınöz, Sacide
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2020-04-08T12:22:04Z
dc.date.available 2020-04-08T12:22:04Z
dc.date.issued 2007-12
dc.identifier.citation Dinç, Erdal; Altynoz, Sacide; Baleanu, Dumitru, "Simultaneous determination of quinapril and hydrochlorothiazide in tablets by ratio spectra derivative spectrophotometric and chemometric methods", Revista De Chimie, Vol.58, No.12, pp.1263-1267, (2007). tr_TR
dc.identifier.issn 0034-7752
dc.identifier.uri http://hdl.handle.net/20.500.12416/2973
dc.description.abstract Simultaneous determination of quinapril (QA) and hydrochlorothiazide (HCT) in tablets were accomplished by ratio spectra first order derivative spectrophotometry (graphical method) and chemometric method (numerical method). Both methods do not require any chemical separation step. In the application of two analytical methods, the absorption spectra in the working range of 4.0-20.0 mu g/mL QA and 2.5-12.5 mu g/mL HCT were plotted in the wavelength range of 210-350 nm. In the graphical approach, the absorption spectra of QA and its binary mixtures in the selected spectral range of 210-280 nm were divided by the standard spectrum of 10 mu g/ mL HCT and their absorption spectra were obtained. In the similar way, the ratio spectra of HCT in the wavelength region of 210-350 nm were also obtained by using the standard spectrum of 12 mu g/mL QA. First derivative of the ratio spectra obtained in the above steps were calculated by Delta lambda=5 nm interval for both drugs. Calibration equation functions were obtained by measuring (he ratio spectra derivative amplitudes of the minima at 219.9 nm for QA and 283.2 nm for HCT in the above mentioned spectral ranges for each drug. In the numerical method, the critical wavelengths corresponding to maximum points at 213.0 nm for QA and 220.0 nm for HCT in the zero-order absorption spectra were selected to construct the least squares calibration (CLS). Both graphical and numerical methods developed in this study were completely validated and applied to the quantitative analysts of tablets containing QA and HCT The results obtained from the developed methods were compared with each other as well as to those obtained by classical derivative spectrophotometry, which have different experimental conditions than the previous derivative method, and the difference was not observed statistically significant. tr_TR
dc.language.iso eng tr_TR
dc.publisher Chiminform Data SA tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Quinapril tr_TR
dc.subject Hydrochlorothiazide tr_TR
dc.subject Ratio Spectra First Order Derivative tr_TR
dc.subject Chemometric Method tr_TR
dc.subject Binary Mixture tr_TR
dc.subject Commercial Tablet Formulation tr_TR
dc.title Simultaneous determination of quinapril and hydrochlorothiazide in tablets by ratio spectra derivative spectrophotometric and chemometric methods tr_TR
dc.type article tr_TR
dc.relation.journal Revista De Chimie tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 58 tr_TR
dc.identifier.issue 12 tr_TR
dc.identifier.startpage 1263 tr_TR
dc.identifier.endpage 1267 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bölümü tr_TR


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