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Continuous wavelet transform and chemometric methods for quantitative resolution of a binary mixture of quinapril and hydrochlorothiazide in tablets

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dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2020-04-10T09:33:19Z
dc.date.available 2020-04-10T09:33:19Z
dc.date.issued 2007
dc.identifier.citation Dinç, Erdal; Baleanu, Dumitru, "Continuous wavelet transform and chemometric methods for quantitative resolution of a binary mixture of quinapril and hydrochlorothiazide in tablets", Journal Of The Brazilian Chemical Society, Vol.18, No.5, pp.962-968, (2007). tr_TR
dc.identifier.issn 0103-5053
dc.identifier.uri http://hdl.handle.net/20.500.12416/3044
dc.description.abstract Quantitative resolution of the quinapril and hydrochlorothiazide mixture in tablets was achieved by using continuous wavelet transform and chemometric methods. In the case of the continuous wavelet transform, various continuous wavelet families were tested in order to find the optimum point of the wavelet signal processing technique. The Mexican hat wavelet function was reported to be the optimal one. The Mexican hat wavelet function was applied to the absorption spectra of quinapril and hydrochlorothiazide in the spectral range of 200-320 nm for standard series of drugs in the concentration range of 4.0-20.0 mu g mL(-1) quinapril and 2.5-12.5 mu g mL(-1) hydrochlorothiazide. The calibration functions for quinapril at 230.6 nm and for hydrochlorothiazide at 271.1 nm were calculated based on the relationship between the measurements of continuous wavelet signals and their concentrations. According to the chemometric approach, partial least squares and principal component regression calibrations were constructed by a training set of 21 mixtures, containing two drugs and their corresponding absorbance data, in the wavelength range of 205-290 nm. All proposed methods were validated by the independent analysis of the synthetic mixtures and by the standard addition technique. The application of the methods indicated that their selectivity and the sensitivity were satisfactory. The investigated methods were successfully applied to tablet analysis. tr_TR
dc.language.iso eng tr_TR
dc.publisher Soc Brasileira Quimica tr_TR
dc.relation.isversionof 10.1590/S0103-50532007000500013 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Continuous Wavelet Transform tr_TR
dc.subject Chemometric Method tr_TR
dc.subject Quantitative Resolution tr_TR
dc.subject Quinapril tr_TR
dc.subject Hydrochlorothiazide tr_TR
dc.title Continuous wavelet transform and chemometric methods for quantitative resolution of a binary mixture of quinapril and hydrochlorothiazide in tablets tr_TR
dc.type article tr_TR
dc.relation.journal Journal Of The Brazilian Chemical Society tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 18 tr_TR
dc.identifier.issue 5 tr_TR
dc.identifier.startpage 962 tr_TR
dc.identifier.endpage 968 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bölümü tr_TR


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