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Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods

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dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2020-04-15T20:09:24Z
dc.date.available 2020-04-15T20:09:24Z
dc.date.issued 2002-10-15
dc.identifier.citation Dinç, E.; Baleanu, Dumitru, "Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods" Journal Of Pharmaceutical And Biomedical Analysis, Vol.30, No.3, pp.715-723, (2002). tr_TR
dc.identifier.issn 0731-7085
dc.identifier.uri http://hdl.handle.net/20.500.12416/3151
dc.description.abstract Four chemometric methods were applied to simultaneous determination of cilazapril and hydrochlorothiazide in tablets. Classical least-square (CLS), inverse least-square (ILS), principal component regression (PCR) and partial least-squares (PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometric calibrations a concentration set of the random mixture consisting of the two drugs in 0.1 M HCl and methanol (1:1) was prepared. The absorbance data in the UV-Vis spectra were measured for the 15 wavelength points (from 222 to 276 nm) in the spectral region 210-290 nm considering the intervals of Deltalambda = 4 nm. The calibration of the investigated methods involves only absorbance and concentration data matrices. The developed calibrations were tested for the synthetic mixtures consisting of two drugs and using the Maple V software the chemometric, calculations were performed. The results of the methods were compared each other as well as with HPLC method and a good agreement was found. (C) 2002 Elsevier Science B.V. All rights reserved. tr_TR
dc.language.iso eng tr_TR
dc.publisher Pergamon-Elsevier Science LTD tr_TR
dc.relation.isversionof 10.1016/S0731-7085(02)00359-X tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Chemometric Methods tr_TR
dc.subject Quantitative Determination tr_TR
dc.subject Cilazapril tr_TR
dc.subject Hydrochlorothiazide tr_TR
dc.subject Tablets tr_TR
dc.title Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods tr_TR
dc.type workingPaper tr_TR
dc.relation.journal Journal Of Pharmaceutical And Biomedical Analysis tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 30 tr_TR
dc.identifier.issue 3 tr_TR
dc.identifier.startpage 715 tr_TR
dc.identifier.endpage 723 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen-Edebiyat Fakültesi,Matematik Bölümü tr_TR


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