DSpace Repository

Peptide Nanoparticles (Pnps) Modified Disposable Platform for Sensitive Electrochemical Cytosensing of Dld-1 Cancer Cells

Show simple item record

dc.contributor.author Yaman, Yeşim Tuğçe
dc.contributor.author Akbal, Öznur
dc.contributor.author Bolat, Gülçin
dc.contributor.author Bozdoğan, Betül
dc.contributor.author Denkbaş, Emir Baki
dc.contributor.author Abacı, Serdar
dc.date.accessioned 2020-04-17T10:41:10Z
dc.date.available 2020-04-17T10:41:10Z
dc.date.issued 2018-05-01
dc.identifier.citation Yaman, Yesim Tugce...et al. (2018). "Peptide nanoparticles (PNPs) modified disposable platform for sensitive electrochemical cytosensing of DLD-1 cancer cells", Biosensors & Bioelectronics, Vol. 104, pp. 50-57. tr_TR
dc.identifier.issn 0956-5663
dc.identifier.uri http://hdl.handle.net/20.500.12416/3278
dc.description.abstract A novel diphenylalaninamid (FFA) based peptide nanoparticles (PNPs) modified pencil graphite electrodes (PGEs) for construction of electrochemical cytosensor was demonstrated for the first time in this study. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images revealed the spherical nanostructure of the synthesized FFA based PNPs while attenuated total reflectance-fourier transform infrared (ATR-FTIR) spectra provided information about the structure and conformation of proteins in their structure. Self assembly of PNPs on PGE surface and adhesion of DLD-1 cancer cells on this surface was also characterized by electrochemical measurements. PNP/PGE5 acted as a sensitive platform for simple and rapid quantification of low concentration of DLD-1 cancer cells in early diagnosis using the electrochemical impedance method (EIS). The offered cytosensor demonstrated outstanding performance for the detection of DLD-1 cells by the EIS method. The impedance of electronic transduction was associated with the amount of the immobilized cells ranging from 2 x 10(2) to 2.0 x 10(5) cells mL(-1) with a limit of detection of 100 cells mL(-1). The efficient performance of the cytosensor was attributed to the well-defined nanostructure and biocompability of PNPs on the substrate tr_TR
dc.language.iso eng tr_TR
dc.publisher Elsevier Advanced Technology tr_TR
dc.relation.isversionof 10.1016/j.bios.2017.12.039 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Peptide Nanoparticle tr_TR
dc.subject Diphenylalaninamid Nanoparticles (Ffanps) tr_TR
dc.subject Cancer Cell tr_TR
dc.subject DLD-1 tr_TR
dc.subject Electrochemical Cytosensor tr_TR
dc.subject Impedimetric Sensor tr_TR
dc.title Peptide Nanoparticles (Pnps) Modified Disposable Platform for Sensitive Electrochemical Cytosensing of Dld-1 Cancer Cells tr_TR
dc.type article tr_TR
dc.relation.journal Biosensors & Bioelectronics tr_TR
dc.contributor.authorID 11534 tr_TR
dc.identifier.volume 104 tr_TR
dc.identifier.startpage 50 tr_TR
dc.identifier.endpage 57 tr_TR
dc.contributor.department Çankaya Üniversitesi, Ortak Dersler Bölümü, Seçmeli Dersler Ana bilim dalı tr_TR


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record