Wavelet transform with chemometrics techniques for quantitative multiresolution analysis of a ternary mixture consisting of paracetamol, ascorbic acid and acetylsalicylic acid in effervescent tablets

Abstract

Quantitative multiresolution analysis of paracetamol (PAR), ascorbic acid (AA) and acetylsalicylic acid (ASP) in pharmaceutical samples was carried out by using simultaneous use of discrete wavelet transformation (DWT) and afterward partial least squares (PLS) and classical least squares (CLS) techniques. The desired concentration was obtained using a set of 20 different calibration samples of PAR, AA, and ASP in different concentration ratio. The absorption spectra in the spectral range of 220-305 nm were recorded and their absorption values were measured at 850 points with intervals of Delta lambda = 0. 1 nm. The obtained DWT-CLS and DWT-PLS calibrations were tested by analysing the independent synthetic mixture containing the above subject compounds. The experimental results showed that DWT-CLS and DWT-PLS techniques are suitable for simultaneous determination of PAR, AA and ASP in samples. The obtained results were compared with those in literature.