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Spectrophotometric determination of acetaminophen and chlorzoxazone in tablets by multivariate calibration techniques

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dc.contributor.author Dinç, Erdal
dc.contributor.author Özdemir, Abdil
dc.contributor.author Onur, Feyyaz
dc.contributor.author Baleanu, Dumitru
dc.contributor.author Aksoy, Halil
dc.contributor.author Yücesoy, Cem
dc.date.accessioned 2016-03-31T12:36:42Z
dc.date.available 2016-03-31T12:36:42Z
dc.date.issued 2006-04
dc.identifier.citation Dinç, E...et al. (2006). Spectrophotometric determination of acetaminophen and chlorzoxazone in tablets by multivariate calibration techniques.Revista De Chimie, 57(2), 368-373. tr_TR
dc.identifier.issn 0034-7752
dc.identifier.uri http://hdl.handle.net/20.500.12416/799
dc.description.abstract Three multivariate techniques, Inverse Least Squares (ILS), Principal Component Regression (PCR) and Partial Least Squares (PLS) were applied to the spectrophotometric determination of acetaminophen (AC) and chlorzoxazone (CL) in tablets without prior separation. Stock solutions of acetaminophen and chlorzoxazone were prepared in methanol. Standard solutions were obtained by dilution of stocks with 0.1 M HCl. The multivariate calibrations were built up using training set containing both drugs in different concentration ratios and measuring the absorbances at 14 wavelengths with 5-nm intervals over the wavelength-range of 210-310 nm. Chemometric calculations were performed with MATLAB 7.0 software, The proposed techniques were applied to a commercial formulation, which contains 300 mg AC and 250 mg a(n=10). The results were statistically compared with each other, as well as those obtained by the developed HPLC method. tr_TR
dc.language.iso eng tr_TR
dc.publisher Chiminform Data S A tr_TR
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Multivariate Spectral Analysis tr_TR
dc.subject HPLC Method tr_TR
dc.subject Acetaminophen tr_TR
dc.subject Chlorzoxazone tr_TR
dc.subject Pharmaceutical Tablet tr_TR
dc.title Spectrophotometric determination of acetaminophen and chlorzoxazone in tablets by multivariate calibration techniques tr_TR
dc.type article tr_TR
dc.relation.journal Revista De Chimie tr_TR
dc.contributor.authorID 6981 tr_TR
dc.contributor.authorID 26096 tr_TR
dc.contributor.authorID 3512 tr_TR
dc.identifier.volume 57 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 368 tr_TR
dc.identifier.endpage 373 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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