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Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by HPLC

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dc.contributor.author Dinç, Erdal
dc.contributor.author Özdemir, Abdil
dc.contributor.author Aksoy, Halil
dc.contributor.author Üstündağ, Özgür
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2016-04-01T08:18:20Z
dc.date.available 2016-04-01T08:18:20Z
dc.date.issued 2006-04
dc.identifier.citation Dinç, E...et al. (2006). "Chemometric determination of naproxen sodium and pseudoephedrine hydrochloride in tablets by HPLC", Chemical & Pharmaceutical Bulletin, 54(4), 415-421. tr_TR
dc.identifier.issn 0009-2363
dc.identifier.uri http://hdl.handle.net/20.500.12416/810
dc.description.abstract A new chemometric determination by high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was implemented for the simultaneous determination of naproxen sodium and pseudoephedrine hydrochloride in tablets. Three chemometric calibration techniques, classical least squares (CLS), principle component regression (PCR) and partial least squares (PLS) were applied to the peak area at multiwavelength PDA detector responses. The combinations of HPLC with chernometric calibration techniques were called HPLC-CLS, HPLC-PCR and HPLC-PLS. For comparison purposes the HPLC method called the classic HPLC method was used to confirm the results obtained from combined HPLC-chemometric calibration techniques. A good chromatographic separation between two drugs with losartan potassium as an internal standard was achieved using a Waters Symmetry (R) C18 Column 5 mu m 4.6 +/- 250 mm and a mobile phase containing 0.2 m acetate buffer and acetonitrile (v/v, 40 : 60). The multiwavelength PDA detection was measured at five different wavelengths. The chromatograms were recorded as a training set in the mobile phase. Three HPLC-chemometric calibrations and the classic-HPLC method were used to test the synthetic mixtures of naproxen sodium and pseudoephedrine hydrochloride in the presence of the internal standard. The HPLC-chemometric approaches were applied to real samples containing drugs of interest. The experimental results obtained from HPLC-chemometric calibrations were compared with those obtained by a classic HPLC method tr_TR
dc.language.iso eng tr_TR
dc.publisher Pharmaceutical Soc Japan tr_TR
dc.relation.isversionof 10.1248/cpb.54.415 tr_TR
dc.rights info:eu-repo/semantics/openAccess
dc.subject HPLC-Chemometric Calibration tr_TR
dc.subject Quantitative Determination tr_TR
dc.subject Naproxen Sodium tr_TR
dc.subject Pseudoephedrine Hydrochloride tr_TR
dc.subject Pharmaceutical Preparation tr_TR
dc.title Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by HPLC tr_TR
dc.type article tr_TR
dc.relation.journal Chemical & Pharmaceutical Bulletin tr_TR
dc.contributor.authorID 6981 tr_TR
dc.contributor.authorID 26096 tr_TR
dc.contributor.authorID 105547 tr_TR
dc.identifier.volume 54 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 415 tr_TR
dc.identifier.endpage 421 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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