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-Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets bymultivariate regression methods

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dc.contributor.author Dinç, Erdal
dc.contributor.author Üstündağ, Ögür
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2024-05-14T07:52:16Z
dc.date.available 2024-05-14T07:52:16Z
dc.date.issued 2010-08
dc.identifier.citation Dinç, Erdal; Üstündağ, Özgür; Baleanu, Dumitru. (2010). "Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets bymultivariate regression methods", Drug Testing and Analysis, Vol.2, No.8, p.383-387. tr_TR
dc.identifier.issn 19427603
dc.identifier.uri http://hdl.handle.net/20.500.12416/8254
dc.description.abstract The sole use of pyridoxine hydrochloride during treatment of tuberculosis gives rise to pyridoxine deficiency. Therefore, a combination of pyridoxine hydrochloride and isoniazid is used in pharmaceutical dosage form in tuberculosis treatment to reduce this side effect. In this study, two chemometric methods, partial least squares (PLS) and principal component regression (PCR), were applied to the simultaneous determination of pyridoxine (PYR) and isoniazid (ISO) in their tablets. A concentration training set comprising binary mixtures of PYR and ISO consisting of 20 different combinations were randomly prepared in 0.1 M HCl. Both multivariate calibration models were constructed using the relationships between the concentration data set (concentration data matrix) and absorbance data matrix in the spectral region 200-330 nm. The accuracy and the precision of the proposed chemometric methods were validated by analyzing synthetic mixtures containing the investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to the artificial mixtures were found between 100.0 and 100.7%. Satisfactory results obtained by applying the PLS and PCR methods to both artificial and commercial samples were obtained. The results obtained in this manuscript strongly encourage us to use them for the quality control and the routine analysis of the marketing tablets containing PYR and ISO drugs. Copyright tr_TR
dc.language.iso eng tr_TR
dc.relation.isversionof 10.1002/dta.145 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Isoniazid tr_TR
dc.subject Partial Least Squares tr_TR
dc.subject Principal Component Regression tr_TR
dc.subject Pyridoxine Hydrochloride tr_TR
dc.title -Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets bymultivariate regression methods tr_TR
dc.type article tr_TR
dc.relation.journal Drug Testing and Analysis tr_TR
dc.contributor.authorID 56389 tr_TR
dc.identifier.volume 2 tr_TR
dc.identifier.issue 8 tr_TR
dc.identifier.startpage 383 tr_TR
dc.identifier.endpage 387 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bölümü tr_TR


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