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Fractional wavelet analysis for the simultaneous quantitative analysis of lacidipine and its photodegradation product by continuous wavelet transform and multilinear regression calibration

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dc.contributor.author Dinç, Erdal
dc.contributor.author Ragno, Gaetano
dc.contributor.author Ioele, Giuseppina
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2016-04-05T10:34:32Z
dc.date.available 2016-04-05T10:34:32Z
dc.date.issued 2006-11
dc.identifier.citation 1546 tr_TR
dc.identifier.citation Dinç, E...et al. (2006). Fractional wavelet analysis for the simultaneous quantitative analysis of lacidipine and its photodegradation product by continuous wavelet transform and multilinear regression calibration. Journal of AOAC International, 89(6), 1538-1546. tr_TR
dc.identifier.issn 1060-3271
dc.identifier.uri http://hdl.handle.net/20.500.12416/830
dc.description.abstract Fractional wavelet transform (FWT) was applied to the original absorption spectra of lacidipine (LAC) and its photodegradation product (LACD), and the resulting FWT spectra were processed by continuous wavelet transform (CWT) and multilinear regression calibration (MLRC) for the simultaneous quantitative analysis of both products in their binary mixtures. These methods do not require any chemical separation step and chemical complex reaction to obtain a detectable signal for the degradation product. By using the Mexican hat function, 2 calibration functions for LAC and LACD were obtained by measuring the CWT transformed signals at 416.1 nm for LAC and 414.6 nm for LACD, after FWT processing of the original absorption spectra. The calibration graphs were linear in the concentration range of 5.08-40.64 mu g/mL for LAC and 0.51-8.16 mu g/mL for LACD. The limit of detection and the limit of quantitation were found to be 0.289 and 0.956 mu g/mL for LAC and 0.036 and 0.118 mu g/mL for LACD, respectively. For comparison, the MLRC algorithm was applied to the linear regression functions for the individual drug and its photoproduct. In this approach, a set of linear regression functions was obtained from the relationship between concentrations and FWT signals in the wavelength range 411.0-412.4 nm. Both methods were applied to the quantitative evaluation of LAC and LACD in laboratory and pharmaceutical samples, and produced very satisfactory results tr_TR
dc.language.iso eng tr_TR
dc.publisher AOAC International tr_TR
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Continuous Daubechies tr_TR
dc.subject Effervescent Tablets tr_TR
dc.subject Binary-Mixture tr_TR
dc.subject Ascorbic-Acid tr_TR
dc.subject Hydrochlorothiazide tr_TR
dc.subject Multiresolution tr_TR
dc.subject Multivariate Spectral Calibrations tr_TR
dc.subject Acetylsalicylic-Acid tr_TR
dc.subject Ternary Mixture tr_TR
dc.subject Derivative Spectrophotometry tr_TR
dc.title Fractional wavelet analysis for the simultaneous quantitative analysis of lacidipine and its photodegradation product by continuous wavelet transform and multilinear regression calibration tr_TR
dc.type article tr_TR
dc.contributor.authorID 6981 tr_TR
dc.identifier.volume Journal of AOAC International tr_TR
dc.identifier.issue 89 tr_TR
dc.identifier.startpage 6 tr_TR
dc.identifier.endpage 1538 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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