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Chemometric Methods for the Simultaneous Spectrophotometric Determination of Telmisartan and Hydrochlorotiazide in the Commercial Pharmaceuticals

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dc.contributor.author Beliz, Kaya
dc.contributor.author Dinç, Erdal
dc.contributor.author Baleanu, Dumitru
dc.date.accessioned 2016-05-03T08:55:09Z
dc.date.available 2016-05-03T08:55:09Z
dc.date.issued 2009-06
dc.identifier.citation Beliz, K., Dinç, E., Baleanu, D. (2009). Chemometric Methods for the Simultaneous Spectrophotometric Determination of Telmisartan and Hydrochlorotiazide in the Commercial Pharmaceuticals. Revista De Chimie, 60(6), 544-550. tr_TR
dc.identifier.issn 034-7752
dc.identifier.uri http://hdl.handle.net/20.500.12416/970
dc.description.abstract Simultaneous spectrophotometric determination of telmisartan (TEL) and hydrochlorothiazide (HCT) in two different commercial pharmaceutical preparations were performed by using three different chemometric methods, namely principal component regression (PCR), partial least squares (PLS) and artificial neural network (ANN). The proposed chemometric methods do not require chemical seperation and spectral graphical procedures for the quantitative resolution of mixtures containing the titled compounds. In the preparation of chemometric calibrations, a concentration set of 45 synthetic mixtures containing TEL and HCT in the linear concentration range of 1.0-26.0 and 1.0-17.0 mu g/mL, respectively was simetrically prepared in methanol. The spectra of the above concentration set and samples were recorded in the spectral range of 200-350 nm. Concentration set and its corresponding absorbances in the selected spectral range corresponding to the 250-350 nm wavelength range was used to obtain PCR, PLS and ANN calibrations. Recovery study, intra-day, inter-day and standard addition technique were considered as method validation. Three proposed chemometric approaches were sucessfully applied to the quantitative analysis of two different commercial pharmaceutical products tr_TR
dc.language.iso eng tr_TR
dc.publisher Chiminform Data S A tr_TR
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Partial Least Squares tr_TR
dc.subject Principal Component Regression tr_TR
dc.subject Artificial Neural Networks tr_TR
dc.subject Simultaneous Determination tr_TR
dc.subject Telmisartan tr_TR
dc.subject Hydrochlorotiazide tr_TR
dc.title Chemometric Methods for the Simultaneous Spectrophotometric Determination of Telmisartan and Hydrochlorotiazide in the Commercial Pharmaceuticals tr_TR
dc.type article tr_TR
dc.relation.journal Revista De Chimie tr_TR
dc.contributor.authorID 6981 tr_TR
dc.identifier.volume 60 tr_TR
dc.identifier.issue 6 tr_TR
dc.identifier.startpage 544 tr_TR
dc.identifier.endpage 550 tr_TR
dc.contributor.department Çankaya Üniversitesi, Fen Edebiyat Fakültesi, Matematik Bilgisayar Bölümü tr_TR


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